Radix Polygalae

Tóm tắt

Rễ viễn chí(Radix Polygalae) là rễ khô của cây viễn chí lá nhỏ (Polygala tenuifolia Wild.) hoặc viễn chí Xiberi (Polygala sibirica L.), thuộc họ Viễn chí (Polygalaceace). Viễn chí phân bố chủ yếu ở khu vực Á Âu. Ở Việt Nam, viễn chí vẫn chưa được khai thác nhiều, mới ghi nhận loài Polygala siribica L. có công dụng làm thuốc. Theo tài liệu cổ, viễn chí đắng, tính ôn, vào 2 kinh tâm và thận, dùng tối đa 6g/ngày. Rễ viễn chí dùng trừ đờm, điều trị suy nhược thần kinh, hay quên, sợ hãi, ung thư sưng thũng. Rễ viễn chí chứa nhiều thành phần hoá học như saponin, terpen, oligosaccharides, xanthon với chất tiềm năng là tenuifolin.

I. Thông tin về dược liệu

Định danh

• Dược liệu tiếng Việt: Viễn Chí - Rễ
• Dược liệu tiếng Trung: nan (nan)
• Dược liệu tiếng Anh: nan
• Dược liệu latin thông dụng: Radix Polygalae
• Dược liệu latin kiểu DĐVN: nan
• Dược liệu latin kiểu DĐVN: nan
• Dược liệu latin kiểu thông tư: nan
• Bộ phận dùng: Rễ (Radix)

Mô tả dược liệu

Theo dược điển Việt nam V: nan

Mô tả dược liệu theo thông tư chế biến dược liệu theo phương pháp cổ truyền: nan

Chế biến

Chế biến theo dược điển việt nam V: nan

Chế biến theo thông tư: nan

II. Thông tin về thực vật

Dược liệu Viễn Chí - Rễ từ bộ phận Rễ từ loài Polygala tenuifolia.

Mô tả thực vật: Ở Việt Nam mới có P.sibirica L được ghi nhận có công dụng làm thuốc. Polygala sibirica L. là loại cỏ lâu năm, cao 10-20cm, đường kính của thân cây 1-6mm. Lá mọc so le. Lá phía dưới nhỏ hơn, hình mác dài 0,6-3cm, rộng 3-6mm, ở cả 2 mặt lá đều có lông nhỏ mịn. Hoa mọc thành chùm dài 3-7cm cánh hoa màu lam tím. Quả nang hình trứng dài độ 4-5mm.

Tài liệu tham khảo: “Những cây thuốc và vị thuốc Việt Nam” - Đỗ Tất Lợi Trong dược điển Việt nam, một số loài có thể dùng thay thế cho nhau làm dược liệu bao gồm Polygala tenuifolia, Polygala sibirica

Phân loại thực vật của Polygala tenuifolia

Kingdom: Plantae

Phylum: Tracheophyta

Order: Fabales

Family: Polygalaceae

Genus: Polygala

Species: Polygala tenuifolia

Phân bố trên thế giới: nan, Russian Federation, China, Korea, Republic of, Brazil, Mongolia

Phân bố tại Việt nam: Không có ghi nhận ở Việt Nam

Phân loại thực vật của Polygala sibirica

Kingdom: Plantae

Phylum: Tracheophyta

Order: Fabales

Family: Polygalaceae

Genus: Polygala

Species: Polygala sibirica

Phân bố trên thế giới: China, Mongolia, Ukraine, Russian Federation

Phân bố tại Việt nam: Không có ghi nhận ở Việt Nam

III. Thành phần hóa học

Theo tài liệu của GS. Đỗ Tất Lợi: (1) saponin, xanthon, oligosaccharides, terpen (2) Tenuifolin

Theo cơ sở dữ liệu lotus, loài Polygala sibirica đã phân lập và xác định được 66 hoạt chất thuộc về các nhóm Cinnamic acids and derivatives, Organooxygen compounds, Steroids and steroid derivatives, Benzopyrans trong bảng dưới đây.

chemicalTaxonomyClassyfireClass	smiles_count
Benzopyrans	2246
Cinnamic acids and derivatives	2207
Organooxygen compounds	2199
Steroids and steroid derivatives	73

Danh sách chi tiết các hoạt chất như sau:

Nhóm Benzopyrans.

Nhóm Cinnamic acids and derivatives.

Nhóm Organooxygen compounds.

Nhóm Steroids and steroid derivatives.

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IV. Tác dụng dược lý

Theo tài liệu quốc tế: nan

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V. Dược điển Việt Nam V

Soi bột

nan

Vi phẫu

nan

Định tính

nan

Định lượng

nan

Thông tin khác

• Độ ẩm: nan
• Bảo quản: nan

VI. Dược điển Hồng kong

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VII. Y dược học cổ truyền

nan

Tên vị thuốc: nan

Tính: nan

Vị: nan

Quy kinh: nan

Công năng chủ trị: nan

Phân loại theo thông tư: nan

Tác dụng theo y dược cổ truyền: nan

Chú ý: nan

Kiêng kỵ: nan

Cấu trúc hóa học của các hoạt chất thuộc nhóm Benzopyrans là mangiferin (LTS0009443), lancerin (LTS0008781), 2-[(2s,3r,4s,5s,6r)-3-{[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-1,3,7-trihydroxyxanthen-9-one (LTS0132590), 2-[6-({[(4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl]-1,3,6-trihydroxy-7-methoxyxanthen-9-one (LTS0201040), 2-(3-{[3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)-1,3,7-trihydroxyxanthen-9-one (LTS0274062), 2-[(2s,3r,4r,5s,6r)-6-({[(2r,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl]-1,3,6-trihydroxy-7-methoxyxanthen-9-one (LTS0147299), 7-hydroxy-1-methoxyxanthen-9-one (LTS0108371), 1,3,6-trihydroxy-7-methoxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one (LTS0061399), 1,3,6-trihydroxy-7-methoxy-2-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one (LTS0040617), 1,2,3,7-tetramethoxy-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}xanthen-9-one (LTS0235675), 1,2,3,7-tetramethoxy-6-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}xanthen-9-one (LTS0098797), mangiferin (LTS0238751), 2-[6-({[3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl]-1,3,6-trihydroxy-7-methoxyxanthen-9-one (LTS0078888), 2-[(2s,3r,4r,5s,6r)-6-({[(2r,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl]-1,3,7-trihydroxyxanthen-9-one (LTS0081271), 6-({3,5-dihydroxy-6-methyl-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl}oxy)-1,3-dihydroxy-2,7-dimethoxyxanthen-9-one (LTS0017627), 1,3-dihydroxy-2,7-dimethoxy-6-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}xanthen-9-one (LTS0206825), (2s,3r,4r,5s,6s)-2-[(6,8-dihydroxy-2,7-dimethoxy-9-oxoxanthen-3-yl)oxy]-5-hydroxy-6-methyl-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl acetate (LTS0104766), 1,3,6-trihydroxy-7-methoxy-4-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one (LTS0190511), 1,3,6-trihydroxy-7-methoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one (LTS0201697), 1,3-dihydroxy-2,7-dimethoxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]xanthen-9-one (LTS0153009), (2s,3r,4r,5s,6s)-5-hydroxy-2-[(8-hydroxy-2,7-dimethoxy-9-oxo-6-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}xanthen-3-yl)oxy]-6-methyl-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl acetate (LTS0166999), 1,3,7-trihydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one (LTS0185505), 8-{[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-11-hydroxy-2h-[1,3]dioxolo[4,5-b]xanthen-10-one (LTS0223329), 6-{[(2s,3r,4r,5s,6s)-3,5-dihydroxy-6-methyl-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-1,3-dihydroxy-2,7-dimethoxyxanthen-9-one (LTS0228630), 2-[(6,8-dihydroxy-2,7-dimethoxy-9-oxoxanthen-3-yl)oxy]-5-hydroxy-6-methyl-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl acetate (LTS0236780), 8-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-11-hydroxy-2h-[1,3]dioxolo[4,5-b]xanthen-10-one (LTS0194488), 2-[6-({[3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl]-1,3,7-trihydroxyxanthen-9-one (LTS0024048), 5-hydroxy-2-[(8-hydroxy-2,7-dimethoxy-9-oxo-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}xanthen-3-yl)oxy]-6-methyl-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl acetate (LTS0233502).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Cinnamic acids and derivatives là [(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-{[(2s,3s,4r,5r)-4-hydroxy-3-{[(2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy}-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}oxan-2-yl]methyl (2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0088419), {3,4,5-trihydroxy-6-[(4-hydroxy-3-{[3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy}-2,5-bis(hydroxymethyl)oxolan-2-yl)oxy]oxan-2-yl}methyl 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0164225), (2s,3s,4r,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-2-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl (2e)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate (LTS0201269), (2s,3r,4r,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-2-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl (2e)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate (LTS0257832), {3,4,5-trihydroxy-6-[(4-hydroxy-3-{[3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy}-2,5-bis(hydroxymethyl)oxolan-2-yl)oxy]oxan-2-yl}methyl benzoate (LTS0178896), 4-hydroxy-2,5-bis(hydroxymethyl)-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl 3-(3,4,5-trimethoxyphenyl)prop-2-enoate (LTS0089152), (2s,3s,4r,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-2-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl (2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0009209), [(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-{[(2s,3s,4r,5r)-4-hydroxy-3-{[(2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy}-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}oxan-2-yl]methyl benzoate (LTS0020690), 4-hydroxy-2,5-bis(hydroxymethyl)-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0199845), tenuifoliside d (LTS0076030), [(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-{[(2s,3s,4r,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-3-{[(2e)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}oxolan-2-yl]oxy}oxan-2-yl]methyl 4-hydroxybenzoate (LTS0201897), (2s,3s,4r,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-2-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0262601), [(2r,3s,4s,5r,6r)-6-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl (2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0201846), tenuifoliside a (LTS0191923), 4-hydroxy-2,5-bis(hydroxymethyl)-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxolan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0213059), (6-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl)methyl 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0212902), (3,4,5-trihydroxy-6-{[4-hydroxy-2,5-bis(hydroxymethyl)-3-{[3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}oxolan-2-yl]oxy}oxan-2-yl)methyl 4-hydroxybenzoate (LTS0160018), [(2s,3r,4r,5s,6s)-3,4,5-trihydroxy-6-{[(2s,3r,4s,5r)-4-hydroxy-2,5-bis(hydroxymethyl)-3-{[(2e)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}oxolan-2-yl]oxy}oxan-2-yl]methyl 4-hydroxybenzoate (LTS0037931), [(2r,3s,4s,5r,6r)-6-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl (2e)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate (LTS0195852), 4,5-dihydroxy-6-[(4-hydroxy-3-{[3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy}-2,5-bis(hydroxymethyl)oxolan-2-yl)oxy]-2-(hydroxymethyl)oxan-3-yl 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0054249), (6-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl)methyl 3-(3,4,5-trimethoxyphenyl)prop-2-enoate (LTS0159181), (2r,3s,4r,5r,6r)-4,5-dihydroxy-6-{[(2s,3s,4r,5r)-4-hydroxy-3-{[(2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoyl]oxy}-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-2-(hydroxymethyl)oxan-3-yl (2e)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate (LTS0124363), [(2r,3s,4s,5r,6r)-6-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl (2z)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate (LTS0088301).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Organooxygen compounds là (2s,3s,4r,5r)-2-{[(2r,3r,4s,5r,6r)-4-{[(2r,3r,4s,5r,6r)-6-[(acetyloxy)methyl]-3,5-dihydroxy-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-5-{[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}-6-(hydroxymethyl)-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-2-({[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}methyl)-5-(hydroxymethyl)oxolan-3-yl benzoate (LTS0072640), (2s,3s,4r,5r)-2-{[(2r,3r,4s,5r,6r)-4-{[(2r,3r,4s,5r,6r)-6-[(acetyloxy)methyl]-3,5-dihydroxy-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-5-{[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}-6-(hydroxymethyl)-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-5-(hydroxymethyl)-2-({[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}methyl)oxolan-3-yl benzoate (LTS0033140), (2s,3s,4r,5r)-2-{[(2r,3r,4s,5r,6r)-5-(acetyloxy)-6-[(acetyloxy)methyl]-4-{[(2r,3r,4s,5r,6r)-6-[(acetyloxy)methyl]-3,5-dihydroxy-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-5-(hydroxymethyl)-2-({[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}methyl)oxolan-3-yl benzoate (LTS0097245), (2s,3s,4r,5r)-2-{[(2r,3r,4s,5r,6r)-4-{[(2r,3r,4r,5r,6r)-5-(acetyloxy)-6-[(acetyloxy)methyl]-3-hydroxy-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-[(acetyloxy)methyl]-5-{[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-5-(hydroxymethyl)-2-({[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}methyl)oxolan-3-yl benzoate (LTS0100240), (2s,3s,4r,5r)-2-{[(2r,3r,4s,5r,6r)-4-{[(2r,3r,4r,5r,6r)-5-(acetyloxy)-6-[(acetyloxy)methyl]-3-hydroxy-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-[(acetyloxy)methyl]-5-{[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-5-(hydroxymethyl)-2-({[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}methyl)oxolan-3-yl benzoate (LTS0102031), 2-(hydroxymethyl)oxane-3,4,5-triol (LTS0220233), (2s,3s,4r,5r)-2-{[(2r,3r,4s,5r,6r)-4-{[(2r,3r,4s,5r,6r)-6-[(acetyloxy)methyl]-3,5-dihydroxy-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)-5-{[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-5-(hydroxymethyl)-2-({[(2e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}methyl)oxolan-3-yl benzoate (LTS0048205), 1-(4-{[(2r,3s,4r,5r,6s)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2r,3s,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}phenyl)ethanone (LTS0199383), [(2r,3s,4s,5r,6r)-6-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 4-hydroxybenzoate (LTS0129792), (6-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl)methyl 4-hydroxybenzoate (LTS0181237), 1-(4-{[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}phenyl)ethanone (LTS0220342), [(2r,3r,4s,5r,6r)-6-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 4-hydroxybenzoate (LTS0055452), 1-(4-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}phenyl)ethanone (LTS0248428), 1-(4-{[(2s,3r,4s,5r,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}phenyl)ethanone (LTS0026469).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Steroids and steroid derivatives là 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1h-picene-4,8a-dicarboxylic acid (LTS0016208).